Robert Weber

100k-Core 5D Architecture: Catching AlphaFold's 4.143 Å Tether Violations - RJW

Macromolecular structure prediction remains limited by the $O(N^2)$ scaling of non-bonded interaction evaluations and the absence of strict physical boundary conditions in purely statistical deep-learning models. In the published SARS-CoV-2 spike glycoprotein protomer model (AF-P0DTC2), sequential $C\alpha$ distances r...