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Author

Roberto Cutolo

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Open access Sep 2026

A Thiophilic Metal-Mediated Cysteine S -Detritylation Strategy: Enhancing Orthogonality in Solid-Phase Peptide Synthesis

The selective manipulation of cysteine residues in solid-phase peptide synthesis (SPPS), beyond disulfide bridge formation, remains challenging, and an efficient protocol for the selective removal of the widely used trityl (Trt) protecting group under solid-phase conditions has yet to be established. To overcome this...

Salvatore Mottola, R. Bellavita, I. Boccino et al. · 0 citations

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