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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Roberto Mallone

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Open access Sep 2026

Engineering the insulin signal peptide to protect human pancreatic beta cells from autoimmune destruction.

Autoreactive T cells that destroy beta cells in type 1 diabetes are largely targeting insulin signal peptide fragments. HLA knockout beta-cells have been proposed to create hypo-immune cells, but this strategy poses significant tumorigenic risks. Alternatively, we hypothesized that insulin signal peptide modification w...

Farah Kobaisi, Masaya Oshima, Zhi-Cheng Zhou et al. · 0 citations
Open access Sep 2026

Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes

Where does autoimmune persistence reside in type 1 diabetes (T1D)? Detailed investigation of the pancreas and pancreatic lymph nodes (PLNs) may provide more definitive answers, yet most studies in these target tissues have been confined to mouse models. In nonobese diabetic (NOD) mice, disease development is prevented...

Fatoumata Samassa, Sylvaine You, Roberto Mallone · 0 citations

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