ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicles (EVs), nanosized membranous particles...
B. Whitehead, Maibritt Mardahl, E. P. Hansen et al.· Journal of Extracellular Ves...· 0 citations
The higher S stercoralis haplotype diversity in children compared with dogs suggests that S stercoralis transmission in the human population is complex, likely involving a potentially prevalent human-to-human transmission.
Patsy A. Zendejas-Heredia, Molyden Vann, S. Sar et al.· Lancet Global Health· 0 citations
Parasitic helminth infections impose major burdens on human and animal health, and increasing anthelmintic resistance reinforces the need for new drugs. Early-stage discovery remains constrained by the scarcity of novel, potent, selective and chemically tractable starting points, the limited predictive value of some ex...
A. Taki, B. Sleebs, Timothy N C Wells et al.· Biotechnology Advances· 0 citations
BACKGROUND
Cystic echinococcosis, caused by the tapeworm Echinococcus granulosus sensu stricto (ss), is a globally distributed, zoonotic disease that is recognised by WHO as a neglected tropical disease. Despite its clinical and economic importance, nuclear genomic variation in this parasite has not been systematically...
Liina Anijalg, Pasi K. Korhonen, Neil D. Young et al.· The Lancet Microbe· 0 citations
It is indicated that linked structural and proteolytic responses contribute to chemical sensitivity in H. contortus and how integrative proteomics can resolve organism-level responses to chemical perturbation beyond single-target paradigms is demonstrated.
A. Taki, Nghi H. Nguyen, Tao Wang et al.· Frontiers in Pharmacology· 0 citations
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