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Author

Robin Curtis

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Open access Sep 2026

Beyond classical electrostatic screening: Non-specific binding of adenosine triphosphate drives long-range protein repulsion.

Overcharging of proteins by multivalent phosphate anions, such as adenosine triphosphate (ATP) and tripolyphosphate (TPP), can strongly modulate protein-protein interactions and colloidal stability, yet its physical origin and consequences remain incompletely understood. Here we examine how ATP and sodium tripolyphosph...

Shu-Yuan Tan, Chuen-Hang Choi, Abdullatif Alfutimie et al. · 0 citations
Review Open access Jul 2026

Adenosine triphosphate as a modulator of protein interactions and stability

Beyond its classical role as the cellular energy currency, adenosine triphosphate (ATP) can directly modulate protein stability, solubility and self‐assembly through weak nonspecific interactions. Here, we summarise the current experimental and theoretical understanding of noncanonical ATP–protein interactions and thei...

Shu-Yuan Tan, Robin Curtis · 0 citations

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