Robin M. Murray

Genetic risk of psychopathology predicts environmental risk

Environmental risk factors for psychosis and psychopathology are often treated as non-genetic, although many are partly heritable or correlated with genetically influenced traits. We tested nine polygenic scores against 49 environmental-risk factors in 307,493 UK Biobank participants without recorded schizophrenia, b...

An etiological approach to psychosis: potential benefits for treatment, research and prevention

Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study

Findings provide proof-of-concept for the utility of pPGSs in psychiatric research, suggesting both genetic contributions to trauma exposure and GxE effects on psychosis risk, as well as supporting pathway-specific contributions beyond general polygenic risk.