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Author

Rocio Diaz Escarcega

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Open access Sep 2026

Stress-induced helicase DHX36 controls neuroinflammation.

Neurons in the aging brain experience sustained inflammatory, proteostatic, and genotoxic stress, accompanied by the accumulation of non-canonical nucleic acid structures such as G-quadruplexes (G4s). Using a G4-binding probe and mass spectrometry, we identified the G4 helicase DHX36 enriched in the aged mouse brain, p...

V. J., Rocio Diaz Escarcega, Chun-Feng Tan et al. · 0 citations
Sep 2026

HUWE1 interactomes reveal sex-specific networks of nucleic acid-binding proteins.

HUWE1 (HECT, UBA, and WWE domain-containing protein 1) is an X-linked E3 ubiquitin ligase that regulates a broad range of substrates through both degradative and non-degradative ubiquitination. The essential role of HUWE1 is underscored by the neonatal lethality of Huwe1 knockout mice. Although HUWE1 has been extensive...

Rocio Diaz Escarcega, M. J. Vijay Kumar, Azeez Abdul et al. · 0 citations

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