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Rodrigo Romero

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Open access Jul 2026

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development

A pro-tumorigenic IL-1β/IL-6 signaling circuit mediated through local macrophages and fibroblasts is identified that unleashes the full oncogenic potential of a cancer driver activated at the PIN stage, with implications for TME-specific targeted therapeutics in early-stage disease.

Young-Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz et al. · 0 citations

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