Review
Jul 2026
Turning the Sulfur Dial: Strategic Oxidation-State Manipulation in Modern Drug Discovery.
Sulfur occupies a distinct niche in the toolkit of a medicinal chemist. Unlike oxygen, sulfur rationalized by ionic-resonance, negative hyperconjugation into low-lying σ* orbitals, and high polarizability of its 3p valence shell, accommodates the oxidation states from -2 to +6, adopting a diverse range of molecular geo...
Anam Sania Md. Arshad, Rohit Singh, A. Wiemer
· Journal of Medicinal Chemist... · 0 citations