Author

Romain Koszul

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Open access Oct 2026

Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans

Rather than restoring the pre-injury regulatory landscape wholesale, appendage regeneration in these two pancrustacean models proceeds through a conserved sequence of genome-wide chromatin resetting, selective regulatory reopening and activation of a pioneer transcription factor.

Maëlle Louvier, Gillian Forbes, Mahmood Mohammed-Ali et al. · bioRxiv · 0 citations

Open access Dec 2025

Bacteriophage PAK_P3 genome structuration and dynamics during infection of Pseudomonas aeruginosa reveal specific interaction patterns

This work explores the spatial dynamics of the virulent double-stranded DNA phage PAK_P3 during infection of its host Pseudomonas aeruginosa and reveals how its genome rapidly decondenses to adopt a specific 3D organization that reflects its transcriptional program.

Amaury Bignaud, Quentin Lamy-Besnier, Devon E. Conti et al. · bioRxiv · 1 citation

Open access Aug 2026

Chromatin is dispensable for bacterial life

The successful construction of ΔNAP9 demonstrates that bacterial cells can carry out basic cellular functions in the absence of co-evolved chromatin proteins, highlighting the potential for radical (re-)engineering of prokaryotic chromatin and systems of gene expression.

Paul Villain, A. Hocher, Jacques Serizay et al. · bioRxiv · 1 citation