Romaisaa Boudza

N‐(1H‐Indazolyl) Aryl Sulfonamide Hybrids as Potential Dihydropteroate Synthase Inhibitors: In Vitro Antibacterial Activity Against Escherichia coli and Staphylococcus aureus and Computational Modeling

Antimicrobial resistance (AMR) has severely compromised the clinical utility of classical sulfonamide antibiotics, primarily owing to the emergence of resistance‐associated dihydropteroate synthase variants. In this study, sixteen N‐(1H‐indazolyl) aryl sulfonamide hybrids were evaluated as potential DHPS inhibitors aga...