Hybrid Liposomes with Pyrrolidinium Surfactants for the Encapsulation of Hydrophilic Drugs: Physicochemical Characterization and Cellular Uptake
Pyrrolidinium amphiphiles bearing a hydroxyethyl fragment [MPSn(OH), where n = 12, 14, 16, 18] were used as a modifier for the preparation of cationic hybrid liposomes based on phosphatidylcholine and cholesterol. The composition of the nanocarriers was optimized by varying the surfactant alkyl chain length and the lip...