Author

Ronald J. Sokol

2 papers indexed here

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Open access Aug 2026

An FGF21-IGFBP1 tumor-liver relay drives musculoskeletal defects in colorectal cancer cachexia

Colorectal cancer (CRC) is frequently accompanied by cachexia, a wasting syndrome characterized by progressive loss of muscle and bone that worsens physical function and survival. Although liver dysfunction is increasingly recognized in cachexia, whether tumor-induced liver signaling contributes directly to musculosk...

J. Huot, Urja R. Kamdar, Caleb J. Gammon et al. · Nature Communications · 0 citations

Open access Oct 2026

Role of HIF1α in FXR-mediated protection and anti-inflammatory macrophage polarization in parenteral nutrition-associated cholestasis.

Parenteral nutrition-associated cholestasis (PNAC) arises from suppressed FXR signaling and macrophage activation driven by intestinal LPS and PN-derived phytosterols. We investigated whether tissue hypoxia and HIF1α signaling play a role in FXR-mediated protection in PNAC. PNAC mouse intrahepatic mononuclear cells (IH...

Swati Ghosh, M. Devereaux, David J. Orlicky et al. · Biochimica et Biophysica Act... · 0 citations