A review of engineering hyaluronic acid-ZIF based nanomaterials for multifunctional disease treatment: Current status and future perspectives.
The hyaluronic acid (HA)-surface-modified zeolitic imidazolate frameworks (ZIFs) nanoplatform enables active targeting by specifically binding to the CD44 receptor highly expressed on tumor and inflammatory cells. Additionally, the high concentration of hyaluronidase in the lesion microenvironment under weakly acidic c...