Jul 2026
TRPV-1-targeted Fe-phenolate network provokes apoptosis and ferroptosis to treat non-small cell lung cancer.
A TRPV1-targeting approach that self-delivers intracellular irons and TRPV1 agonist (N-oleoyldopamine, OLDA) to provoke simultaneous apoptosis and ferroptosis in NSCLC is presented and demonstrated that FeOLDA effectively suppresses tumor growth without weight loss or multi-organ toxicity associated with cisplatin.
Ziyi Wang, Liang Shao, Chunbao Wang et al.
· Biomaterials Science · 0 citations