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Rong Liang

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Open access Aug 2026

Lactate-Induced H3K18 Lactylation Attenuates T-Cell Activation and Upregulates PD-L1 in Esophageal Squamous Cell Carcinoma

Background: Immune checkpoint blockade targeting the Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) axis has demonstrated clinical activity in esophageal squamous cell carcinoma (ESCC). However, therapeutic responses remain limited in a substantial proportion of patients. Metabolic reprogramming and lactat...

Tao Liu, Guang-Sen He, Wen-Shou Zhong et al. · 0 citations

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