Review
Open access
Oct 2026
Context-dependent cGAS–STING signaling in inflammatory bowel disease: cell specificity, lesion state, and therapeutic windows
Whether cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling should be inhibited in inflammatory bowel disease (IBD) cannot be answered from pathway abundance alone. Canonical ER–Golgi–TBK1–IRF3/NF-κB signaling can amplify intestinal inflammation, whereas nuclear STING–AHR signaling, T-cell-i...
Hui-Xi Bian, Wen-Jing Jin, Yu-Hong Chen et al.
· Frontiers in Immunology · 0 citations