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Author

Rong-Xin Chang

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Open access Sep 2026

Dual DNMT–EZH2 Inhibition as a Stroma-Directed Strategy in Castration-Resistant Prostate Cancer: A Commentary

Background: Castration-resistant prostate cancer (CRPC) remains a lethal progression state despite androgen-deprivation therapy, driven by epigenetic plasticity and a fibrotic tumour microenvironment. Single-agent epigenetic inhibitors have limited activity in solid tumours, partly because compensatory H3K27me3-mediate...

Rong-Xin Chang, Guo-Dong Liu · 0 citations
Review Open access Aug 2026

AR-V7-Driven Mitochondrial Metabolic Reprogramming in Enzalutamide-Resistant Prostate Cancer: Mechanisms and Therapeutic Implications

Enzalutamide resistance in castration-resistant prostate cancer (CRPC) is frequently driven by androgen receptor splice variant 7 (AR-V7), a prognostic biomarker that lacks the ligand-binding domain and evades enzalutamide inhibition; however, the downstream metabolic networks sustaining resistant-cell survival remain...

Rong-Xin Chang, Zhuangzhuang Zhang · 0 citations

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