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Review Open access Sep 2026

AAV-mediated gene therapy for Alzheimer’s disease: neuroprotective mechanisms and translational challenges

Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for...

Ze-Hua Yu, Yang Li, Ze-Yu Zhang et al. · 0 citations

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