Open access
Jul 2026
RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity.
Transcription blockage frequently occurs in tumor cells, and aberrant R-loop formation during this process drives genome instability. However, the regulation of R-loop homeostasis and its contribution to tumorigenesis remain to be investigated. Here, we report that the RNA exonuclease REXO4 resolves R-loops by 3'-5' ex...
Jieyou Zhang, Kaiwen Bao, Yayan Hou et al.
· Molecules and Cells · 0 citations