Rongting Huang

stCNASim: Allele-aware spatial RNA-seq simulator enables systematic benchmarking of copy number inference

Spatial transcriptomics (ST) is revolutionizing the study of tumor evolution by enabling spatially resolved copy-number alteration (CNA) analysis. However, evaluating the accuracy and robustness of current single-cell (SC) and ST-specific CNA inference tools remains challenging due to the absence of ground-truth datase...