Oct 2026
Molecular glue degraders of CK1α remodel lysosomes and limit ferroptosis in glioblastoma stem-like cells
Jane Jardine, Margaux Le Guyon, K. Trillet et al.
· bioRxiv · 0 citations
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Aug 2026
The kinase CK1α coordinates the initiation and termination of the cGAS-STING pathway.
It is reported that Casein Kinase 1 alpha operates as a bimodal regulator of the cGAS-STING pathway, and selective degradation of CK1α using molecular-glue degraders suppressed aberrant cGAS-STING-driven inflammation signaling in a chromosomally unstable triple-negative breast cancer cell line.
Jane Jardine, Marine Tarrillon, G. André-Grégoire et al.
· Cell Death and Differentiati... · 0 citations