Author

Rowan Ives

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Open access Sep 2026

Steric control of signaling bias in the immunometabolic receptor GPR84

Biased signaling in G protein-coupled receptors offers therapeutic promise, yet rational design of biased ligands remains challenging due to limited mechanistic understanding. Here, we report a molecular basis for controlling signaling bias at the immunometabolic receptor GPR84. We identify three structurally-match...

Pin-Qi Wang, Xuan Zhang, Abdul-Akim Guseinov et al. · Nature Communications · 0 citations