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Author

Roy R Parker

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Open access Oct 2026

METTL3 inhibition attenuates the macrophage type I interferon response

Macrophages coordinate inflammatory responses to changing tissue conditions and invasion by pathogens. Post-transcriptional regulation of the transcriptome via RNA decay is a crucial element of these responses. N6-methyladenosine (m6A) deposition on mRNA constitutes one such post-transcriptional pathway, where the meth...

Edward M. C. Courvan, Cody J. S. Hecht, Frederick Longshore-Neate et al. · 0 citations
Open access Aug 2026

m6A depletion attenuates the macrophage type I interferon response

It is found that in THP1-derived and peripheral blood macrophages, m6A depletion with the METTL3 inhibitor STM2457 leads to enhanced proliferation of the human coronavirus OC43 and it is concluded that macrophages depend on m6A to support expression of interferon sensing machinery and in m6A’s absence, fail to mount as...

E. Courvan, Cody J. S. Hecht, Frederick Longshore-Neate et al. · 0 citations

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