Rsc Adv

Synthesis, characterization, crystal structures, antitumor activity, and computational study of novel thiosemicarbazone derivatives from thiazol-2/5-carbaldehyde

Design, synthesis, and biological evaluation of naphthalimide derivatives as dual monoamine oxidase-B and amyloid-b aggregation inhibitors for Alzheimer's disease

Modulation of catholyte ionic strength for enhanced bioelectricity generation and bioremediation of tannery wastewater in photosynthetic microbial fuel cells

Photosynthetic microbial fuel cells (PMFCs) represent an emerging class of bio-electrochemical systems capable of converting organic pollutants into electricity through microbial catalysis. Catholyte ionic strength is a principal determinant of PMFC performance, governing electrolyte conductivity, internal resistance,...

Iodine-mediated 2,5-di(aryl/heteroaryl)-1,3,4-oxadiazoles: synthesis, and in vitro and in silico studies of anticancer and antifungal properties

The synthesis of a series of novel 2,5-di(aryl/heteroaryl)-1,3,4-oxadiazole derivatives using molecular iodine under basic conditions identifies 9b and 9g as promising lead 1,3,4-oxadiazole derivatives for further development as anticancer agents.

Hydrazone–heterocyclic hybrids as promising anticancer agents: a comprehensive review

This review focuses on the anticancer activities of heterocycle–hydrazone hybrids derived from quinoline, indole, triazole, benzimidazole and isatin, their in vitro cytotoxic results, the proposed mechanism of action of the most active compound, cell death pathway results, docking studies, and cell cycle-arrest results...

Development of a chitosan/polyethylene oxide/ginger nanocomposite: structural characterization and antibacterial performance

The development of bio-based antibacterial materials using natural additives is a crucial strategy for reducing reliance on hazardous synthetic chemicals. This study investigated the effect of incorporating ginger nanoparticles (GNPs) at varying concentrations (1, 2, 3, and 4 mL) into a chitosan/polyethylene oxide (PEO...

Dihydropyrimidinone–isatin hybrids as potent inducers of cell-cycle arrest and caspase-dependent apoptosis in MV4-11 acute myeloid leukemia cells

Overall, the cytotoxic effects of 7k on MV4-11 cells are attributed to the coordinated induction of ROS-mediated oxidative stress, G0/G1 cell cycle arrest, and caspase-dependent apoptosis, highlighting its promising antiproliferative potential.