Author

Ru-Dong Li

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Review Open access Aug 2026

Isoform-resolved 14-3-3/YWHA networks in colorectal cancer: phospho-adaptor mechanisms, biomarker contexts and therapeutic opportunities

YWHA/14-3-3 proteins are conserved phosphoserine/phosphothreonine-binding adaptors that coordinate signaling-complex assembly, subcellular localization, stress responses and cell-state transitions. Although often discussed as a single adaptor family, colorectal cancer (CRC) studies suggest that individual YWHA isoforms...

Qian Liu, Ru-Dong Li, Wei Ye et al. · Frontiers in Oncology · 0 citations

Review Open access Sep 2026

Aminoacyl-tRNA synthetases in tumor immunity: canonical translation, source-resolved immune circuits and therapeutic opportunities

Aminoacyl-tRNA synthetases (aaRSs) generate the aminoacyl-tRNA pool required for protein synthesis, yet selected family members also participate in nutrient sensing, stress adaptation, metabolite-dependent protein modification and extracellular immune communication. This dual biology creates a recurrent interpretive pr...

Zhi-Peng Zhao, Ru-Dong Li, Si-Yi Wang et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

Elevated intron retention implicates neuroinflammation in brains of individuals with alcohol use disorder

It is shown that chronic alcohol consumption promotes an overall increase of intron retention in the brain and is associated with the presence of double-stranded RNA, which may contribute to neuronal loss and brain pathology by activating a neuroinflammatory response.

Ru-Dong Li, Jill L. Reiter, Season K. Wyatt-Johnson et al. · Brain Communications · 0 citations