Sep 2026
Self-Reinforced DNase-Based Nanosystem With Accelerated Biofilm Disruption and Boosted Antibiotic Delivery for Bacterial Keratitis Therapy.
Biofilm-associated infections remain refractory to antibiotics due to the extracellular polymeric substance (EPS) barrier limiting drug penetration and promoting drug resistance genes transfer. Deoxyribonuclease I (DNase I)-based strategies designed to degrade the EPS scaffold paradoxically fail within the biofilm micr...
Rui Wang, Yan Song, Jun-Jia Zeng et al.
· Advanced Healthcare Material... · 0 citations