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Author

Ru M. Wen

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Open access 2026

AZGP1 deficiency promotes chronic kidney fibrosis in aging mice.

OBJECTIVES Chronic kidney disease (CKD) affects 10-14% of the global population and is a leading cause of death. A hallmark of CKD is renal fibrosis, characterized by excessive extracellular matrix deposition. Although our understanding of fibrogenic mechanisms has advanced, effective antifibrotic therapies are lacking...

Ru M. Wen, Eric E. Peterson, James D. Brooks · 0 citations
Aug 2026

Transforming Growth Factor β3 (TGF-β3) Signaling: A Potential Target for Cancer Therapy.

Transforming growth factor β (TGF-β) signaling is essential for early embryonic development, tissue and organ formation, immune surveillance, tissue repair, and maintaining homeostasis in adults. The three isoforms of TGF-β, TGF-β1/2/3, share a structurally conserved secretion signal peptide and activate various downst...

Zan-Wen Zuo, Wen-Jing Tang, Qian Zhang et al. · 0 citations

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