Author

Ru-Yue Chen

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Open access Sep 2026

A dual role of AcSDKP in chronic kidney disease: Targeting pericyte-driven fibrosis and vascular repair via VEGF/FGFR1 while eliciting a compensatory FGFR1 upregulation in apoptotic tubular cells

Background Renal interstitial fibrosis and peritubular capillary (PTC) rarefaction drive the progression of chronic kidney disease (CKD). While N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous anti-fibrotic peptide, its specific effects on pericyte-endothelial crosstalk and tubular epithelial survival re...

Shi-Yi Zhu, Ling-Li Shi, Lin-Lin Huang et al. · PLoS ONE · 0 citations

Jul 2026

Integrating Methylation Signature Modifications and Subtype Classification into a Prognostic Risk Model for Survival Prognosis and Predicting Immunotherapy Response in Colorectal Cancer.

This study shows that the integrated analysis of multiple RNA methylation modifications provides a more comprehensive view of epitranscriptomic heterogeneity in CRC than single-modification approaches and suggests that multi-modification-based models may improve prognostic accuracy and help identify CRC patients who ma...

Ru-Yue Chen, Zeng-Wu Yao, Li-Xin Jiang et al. · Current Medicinal Chemistry · 0 citations