Author

Ruchi Sharma

h-index 4 View on Semantic Scholar

We have 3 of 21 papers

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Review Open access Sep 2026

The Biology and Cell Engineering of Retinal Pigment Epithelium Cell Transplantation: Developing a Living Drug.

Age-related macular degeneration (AMD) is a multifactorial retinal disease that causes progressive vision loss, with retinal pigment epithelium (RPE) atrophy representing a key initiating event. The RPE monolayer plays a crucial role in maintaining photoreceptor and choriocapillaris health and function. In advanced AMD...

Sudipta Mahato, Elena Daniele, Colby F. Lewallen et al. · Annual Review of Vision Scie... · 0 citations

Open access Aug 2026

Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.

This study develops induced pluripotent stem cell-derived RPE models (iRPE) and identifies two drugs, pioglitazone, a mitochondrial metabolic modulator, and galunisertib, a TGFBR1 inhibitor, as potential therapeutic candidates for multiple ciliopathy subtypes.

Dominik Reichert, Sena Gul, D. Ortolan et al. · Cell Reports · 0 citations

Open access Jul 2026

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated caspase-1 inhibition

A peripheral RPE subpopulation is identified through spatial, transcriptomic, and functional analyses, thereby contributing to the understanding of the heterogeneity of degenerative RPE cells and highlighting SERPINE3 as a protective factor with therapeutic potential for macular atrophy.

Hui-Rong Li, Takerra K. Johnson-Stephenson, Vincent P. Kunze et al. · Journal of Clinical Investig... · 0 citations