Author

Ruchira Singh

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Open access Aug 2026

Design and Application of a µSiM Outer Blood-Retinal Barrier (OBRB) Model as a Drug Development Tool

The outer blood-retinal barrier (OBRB) is the primary interface through which systemically circulating drugs reach the retina. A tool that measures delivery across this barrier would support the development of targeted therapies as alternatives to repeated intravitreal injection, and the screening of drugs that reach t...

Kevin C. Ling, Jordan Jones, Gram Hepner et al. · bioRxiv · 0 citations

Aug 2026

A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.

Disruption of the photoreceptor-retinal pigment epithelium (RPE) interface, with loss of photoreceptor outer segments (POSs) in the retina, is a pathological hallmark of several neurodegenerative and retinal diseases, including lysosomal storage disorders like juvenile neuronal ceroid lipofuscinosis (CLN3) disease. How...

Jimin Han, Nathaniel Foley, Sonal Dalvi et al. · Science Translational Medici... · 0 citations