Open access
Jul 2026
Hippocampal mediation in the lipid–Alzheimer's disease pathway: A high‐dimensional mediation analysis stratified by APOE and sex
The left hippocampus is a critical mediator linking specific plasma lipids to AD progression, with an additional vascular pathway via white matter hyperintensities emerging after comorbidity adjustment, supporting a dual neurodegenerative–vascular pathway.
Yun-Jia Cao, Yu-Wei Fan, Qing-Tao Meng et al.
· Alzheimer's & Dementia · 0 citations