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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Rui Chen

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Open access Aug 2026

SEI1 complex silences p53 to drive myeloma progression

Summary SEI1 is overexpressed in multiple myeloma and correlates with poor prognosis. In this study, we identify SEI1 as a crucial driver of myeloma pathogenesis through a previously unrecognized mechanism: transcriptional inactivation of the tumor suppressor p53. Mechanistically, SEI1 forms a transcriptional complex w...

Rui Chen, Rui Liu, Zhi-Hong Fang et al. · 0 citations

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