A comprehensive and updated synthesis of Polθ's structural architecture, regulatory networks, and context-dependent functions across major malignancies, including ovarian, breast, lung, and colorectal cancers, and a critical evaluation of current Polθ inhibitors.
Ming-Dian Lei, Yuxuan Li, Zhi-Peng Xie et al.· Biochemical and Biophysical...· 0 citations
Findings establish MED24 as a R-loop regulator that enhances SN-38 sensitivity, thereby revealing a previously uncharacterized biological function for MED24 and suggesting a potential therapeutic strategy for TNBC.
Tao Shen, Xin-Hua Liu, Pei Huang et al.· Cell Death & Disease· 0 citations
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