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Review Open access Aug 2026

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

This review systematically explores AI applications in TPD development, covering the prediction and design of stable ternary complexes, rational optimization of linkers, high‐throughput screening for E3 ligase ligands, and accurate predictions of degradation efficiency and ADMET properties.

Shuanglin Qin, Rui Peng, Guangshuai Zhang et al. · 0 citations