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Author

Rui Su

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Open access Sep 2026

Pharmacologically Targeting DHODH-Dependent Pyrimidine Metabolism with HSA-Conjugated BRQ Suppresses Leukemogenesis

Background: Metabolic reprogramming is a hallmark of acute myeloid leukemia (AML) and provides a rich source of therapeutic vulnerabilities. Among these, de novo pyrimidine biosynthesis has emerged as an important metabolic dependency, yet its contribution to AML progression remains incompletely defined. DHODH, a rate-...

Xiao-Xu Zhang, Chang-Hao Tian, Yang Ding et al. · 0 citations
Review Open access Jul 2026

Mitochondrial RNA modifications in gene expression and cancer biology.

All currently known mt-RNA modifications, their potential regulatory machinery, as well as their biological functions in tumorigenesis and metabolism are summarized.

Haixia Wang, Lili Ren, Dongling Zou et al. · 0 citations

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