Open access
Jul 2026
Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers.
A first-in-class small-molecule inhibitor is identified that blocks E7-ZER1 association, restores Rb stability, and selectively suppresses HPV-positive tumor growth in vivo and nominate the ZER1 degron pocket as a ligandable therapeutic target for HPV-driven malignancies, highlighting translational opportunities for ta...
Xiao-Lu Wang, Chenhao Jiang, Yue-Ling Zhao et al.
· Cell Reports · 0 citations