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Review Open access Sep 2026

Neuroplastic mechanisms of chronic pain: Implications and future directions

Chronic pain is now increasingly viewed as aberrant neuroplasticity rather than a protracted expression of peripheral nociception. This review integrates current knowledge through the lens of a peripheral-to-central paradigm, whereby peripheral sensory sensitization contributes to pain initiation, spinal excitation–inh...

Kai-Kai Wang, Yan-Hui He, Jin-Hai Liu et al. · 0 citations

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