Author

Rui-zhi Tan

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Open access Sep 2026

Long non-coding RNA-gm33782 exacerbates acute kidney injury by upregulating the PA1-MLL3/MLL4 complex and promoting histone H3 lysine 4 monomethylation-dependent forkhead box O3 enhancer activation.

As a common clinical syndrome with high morbidity and mortality, acute kidney injury (AKI) involves epigenetic mechanisms that remain largely uncharacterized. In this study, we identify a previously uncharacterized long non-coding RNA mmu-lncR-gm33782 and its human homolog hsa-lncR-CLLU1-AS1 as a critical epigenetic dr...

Rui-Zhi Tan, Jian Jia, Qiu-Xiang Bai et al. · International Journal of Bio... · 0 citations

Sep 2026

Complanatuside Ameliorates Renal Injury and Fibrosis in Chronic Kidney Disease by Inhibiting Tubular Cell Apoptosis via Activation of KLK1/BDKRB2.

BACKGROUND Chronic kidney disease (CKD) is characterized by renal fibrosis as a key pathological feature. Total flavonoids extracted from Astragalus complanatus can effectively alleviate renal fibrosis. However, the anti-fibrotic effect and the underlying specific mechanisms of its main active component, Complanatuside...

Jing Gao, Rui-Zhi Tan, Ke Deng et al. · Journal of Nutritional Bioch... · 0 citations

Review Aug 2026

The Therapeutic Application of Epigenetic Regulation by Natural Herbal Compounds in Kidney Diseases.

Kidney diseases, represented by chronic kidney disease (CKD) and acute kidney injury (AKI), pose significant global public health challenges due to their complex pathogenesis and limited therapeutic options. In recent years, epigenetic regulation-including DNA methylation, histone modifications, and non-coding RNAs-has...

Qiu-xiang Bai, Kang Luo, Long-hao Jia et al. · Seminars in Nephrology · 0 citations