Edwardsiella species are important aquaculture pathogens that also cause opportunistic infections in humans, necessitating efficient genome editing tools to study their pathogenesis and develop control strategies. In this study, we identified and characterized six endogenous recombinases pairs from Edwardsiella and its...
Yun-Jia Deng, Jia-Yu Sun, Hai-Yi Ji et al.· Synthetic and Systems Biotec...· 0 citations
PTEN and p53 are two pivotal tumor suppressors that synergistically restrain tumor progression but are frequently inactivated in cancer. Restoring their functions is a promising therapeutic strategy but remains limited by unsustainable protein production and off-target effects. Here, we report a biohybrid platform inte...
This review articulates a paradigm shift in disorazole research: from confronting the extreme challenge of total chemical synthesis towards harnessing programmable biosynthetic engineering (F & Z), and highlights how key technologies have revolutionized the production and diversification of these molecules.
Guoan Fu, He Li, Ruijuan Li et al.· Journal of Advanced Research· 0 citations
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