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Author

Ruimin Pan

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Open access Jul 2026

A single-domain antibody targets aggregation-prone region of α-synuclein to reduce synucleinopathy, rescue neurodegeneration and improve function

The therapeutic potential of five anti-α-syn single-domain antibodies to clear pathological α-syn in mouse neuronal culture is evaluated and their in vivo efficacy is demonstrated in a Drosophila model of synucleinopathy.

Pragati, E. E. Congdon, Yixiang Jiang et al. · 0 citations

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