Open access
Aug 2026
Targeting host lipogenesis with a diarylamide inhibitor disrupts SARS-CoV-2 replication
Summary The vulnerability of direct-acting antivirals to resistance has motivated interest in host-directed strategies that target conserved cellular pathways essential for viral replication. Here, we report a diarylamide molecule, compound 10 (compd. 10), which inhibits SARS-CoV-2 more potently than the parent clofoct...
Xintian Zhang, Tingfu Du, Yong-Jian Wang et al.
· iScience · 0 citations