Immune Biomarker Profiling Across Clinical States and Development of a SOFA-Integrated Model for 28-Day Mortality Prediction in Sepsis: A Prospective Cohort Study
Background Sepsis is characterized by complex immune dysregulation involving innate immune activation, myeloid stress, and adaptive immune exhaustion. Conventional severity scores mainly reflect organ dysfunction and may not fully capture immune heterogeneity. This study aimed to develop and internally validate an immu...