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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Runjiang Song

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Sep 2026

A Honeybee-Safer Pyrazolyl Pyrido[1,2- a ]pyrimidine Mesoionic Targeting Fall Armyworm nAChR α1/β2 Subunits

Spodoptera frugiperda is a highly destructive pest with widespread resistance to conventional insecticides. Mesoionic chemicals are promising for insecticide discovery, yet lepidopteran-active examples remain limited and many raise pollinator-safety concerns. Here, we report a series of pyrazole-decorated mesoionic p...

Rui-Lan Wang, Shang Wu, Huan Wu et al. · 0 citations
Aug 2026

Carbamate-Modified Pyrido[1,2-a]pyrimidinones: Design and Synthesis of Insecticides with High Efficacy and Low Bee Toxicity.

A set of new pyrido[1,2-a]pyrimidinone derivatives bearing a carbamate moiety attached via a methylene spacer at the 2-position is described, offering a new molecular template for the development of highly selective insecticides.

Qing-Qing Ma, Shang Wu, Luo-Man Zhang et al. · 0 citations
Jul 2026

Novel Pyrazole-Quinoxaline Conjugates as Potent HPPD-Inhibiting Herbicides with Notable Crop Safety.

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a vital target for herbicide development. A series of pyrazole-quinoxaline conjugates were designed and synthesized via scaffold hopping and structural optimization. Bioassays revealed that B9 exhibited potent inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) w...

Li Liu, Mei Zhang, Lingling Wang et al. · 0 citations

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