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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ruoli Wang

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Open access Jul 2026

Integrative single-cell and spatial transcriptomic analysis reveals a lactate-driven crosstalk between NFATc4⁺ tumor cells and SPP1⁺ macrophages in glioblastoma.

BACKGROUND Glioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options. Metabolic reprogramming, particularly lactate metabolism, plays a critical role in tumor progression and immune evasion. METHODS Here, we integrated single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and machine...

Ruoli Wang, Wan-Tao Wu, Xuan Wu et al. · 0 citations

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