IFI44L modulates chemoradiotherapy sensitivity and CD8+ T cell infiltration in colorectal cancer
Objective Chemoradiotherapy (CRT) represents a cornerstone treatment for colorectal cancer (CRC), yet heterogeneous responses to CRT in treatment response remain a major clinical challenge. Increasing evidence suggests that the tumor immune microenvironment (TME) especially intratumoral CD8+ T cells plays an important...