Author

Ruxin Lei

2 papers indexed here

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Open access Sep 2026

Multi-vector retrieval enables residue-resolved prediction of protein partners by ColBERT-PPI

Protein–protein interactions (PPIs) are central to biological processes, making the identification of both interacting partners and their binding sites important for understanding molecular function and guiding therapeutic discovery. However, connecting large-scale partner prediction to residue-level interaction eviden...

He Yang, Ru-Xin Lei, You-Wen Zhuang et al. · bioRxiv · 0 citations

Open access Jul 2026

Molecular principles for graded activation of dopamine D1 receptor

G protein-coupled receptors (GPCRs) signal across a continuum of activation states, yet how ligands encode distinct signaling efficacies remains poorly understood. Here, we define the molecular mechanism underlying graded activation of the dopamine D1 receptor (D1R), a major therapeutic target for neuropsychiatric diso...

Xinyue Zhang, Yu Zheng, Heng Liu et al. · bioRxiv · 0 citations