Open access
Oct 2026
An inducible human LDLR transgenic mouse model for enhanced lentiviral gene delivery to murine immune cells
Lentivirus (LV)-based manipulation of immune cells is a commonly used approach in cell therapies. However, the most frequently used Vesicular Stomatitis Virus Glycoprotein (VSV-G) pseudotyping approach is inefficient to support LV gene delivery of mouse immune cells due to the lack of an optimal entry receptor. Here, w...
Jian Li, Beatriz Goncalves, Gabrielle Melamed et al.
· Frontiers in Immunology · 0 citations