Ryan F. Yoshimura

Voltage-sensor conformational microenvironments encode isoform-selective ion channel activation

Significance Developing drugs that selectively target closely related ion channel isoforms remains a major challenge because these proteins often share highly conserved drug-binding sites. Here, we show that selective activation of Kv7 potassium channel isoforms by the rosemary-derived metabolite carnosic acid (CA) ari...