Author

Ryohei Yamaguchi

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Open access Aug 2026

Distribution-Constrained Optimization for Reliable ML-Guided 5′UTR Sequence Design

A constrained optimization that keeps candidates within a trust region where the predictor’s validated accuracy holds, keeping all candidates inside the trust region while maintaining predicted MRL: under unconstrained optimization most final-generation candidates left the trust region, whereas the hard constraint hold...

Ryohei Yamaguchi, Chinatsu Mori, Sota Inoue · bioRxiv · 0 citations